Understanding Mitochondrial Polymorphisms in Cancer
Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations...
View ArticleUnderstanding Mitochondrial Polymorphisms in Cancer
Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations...
View ArticleThe CDK9 inhibitor dinaciclib exerts potent apoptotic and antitumor effects...
Translocations of the mixed lineage leukemia (MLL) gene occur in 60-80% of all infant acute leukemias and are markers of poor prognosis. MLL-AF9 and other MLL fusion proteins aberrantly recruit...
View ArticleTargeted Inactivation of p53 in Colonic Stem Cells
p53 has been shown to mediate cancer stem–like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to date that have addressed the specific...
View ArticleLysosomal Transport of Noncleavable Maytansine ADC Warhead
Antibody–drug conjugates (ADC) target cytotoxic drugs to antigen-positive cells for treating cancer. After internalization, ADCs with noncleavable linkers are catabolized to amino acid-linker-warheads...
View ArticleTh17 Recruitment via Cervical Cancer-Instructed Fibroblasts
Cervical cancer is a consequence of persistent infection with human papillomaviruses (HPV). Progression to malignancy is linked to an inflammatory microenvironment comprising T-helper-17 (Th17) cells,...
View ArticleEnhancement of Glioblastoma Virotherapy by TGF{beta} Treatment
Oncolytic viruses, including oncolytic herpes simplex virus (oHSV), have produced provocative therapeutic responses in patients with glioblastoma, the most aggressive brain tumor. Paradoxically, innate...
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